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High-risk combinations requiring dose adjustment include insulin and sulfonylureas

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As additional studies are needed to further elucidate the exact mechanism of why the enteric infections occur at a higher rate in PPI users, there is overwhelming evidence that PPI usage can impact the gut microbiota

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10.1152/ajpheart.00758.2006 [DOI] [PubMed] [Google Scholar] Yoboue ED, Sitia R, Simmen T (2018) Redox crosstalk at Endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

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In addition, knockout of other autophagy-related genes, such as ULK1/2, ATG3, and ATG13, also significantly inhibited erastin-induced ferroptosis

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