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Furthermore, early studies reviewed by Reynold and colleagues suggest that one-third of anemic patients would develop neuropsychiatric symptoms if folate deficiencies remained untreated (46)

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NADPH oxidase-dependent ROS production appears to be involved in cardiac hypertrophy in response to pressure overload (140, 141), stretch (142), angiotensin II-infusion (139, 143), and -adrenergic stimulation (144)

Estrogen can enhance autoimmune responses, which partly explains the female predominance of the disease

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