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The widespread use of DPP-4 inhibitors among patients with T2DM and advanced age, who are more predisposed to osteoporosis, underscores the need for a better understanding of the relationship between DPP-4 enzyme activity, its substrates, pharmacological inhibition, and bone metabolism

15 Cognitive disorders, sleep disorders, and hearing disorders such as, tinnitus, hearing loss, and central auditory processing disorder are also common

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The introduction of Semaglutide in this subgroup resulted in partial recapture of WL, with %EWL increasing to 68% at three years, though this effect appeared to wane by year five