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Important cautions: History of medullary thyroid carcinoma (MTC) or MEN2 , pancreatitis , gallbladder disease, severe GI disorders, certain drug interactions, and pregnancy/breastfeeding considerations

Safety profile The safety assessment of GLP-1 receptor agonists indicates a mostly gastrointestinal side effect profile, characterised by dose-dependent symptoms that are often treatable by meticulous titration (Madsbad 2016)

Activity assays

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Retatrutide, on the other hand, targets the same hormones as Zepbound plus one other: glucagon