tirzepatide and macular degeneration The Link between GLP-1 Drugs Diabetic Retinopathy Is Not So Clear | AAO 2024 GLP-1 Drugs Linked to Higher

Researchers noted that tirzepatide is a glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist originally created for Type 2 diabetes

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In the present study, the upregulation of PCSK5 expression was primarily at the border and infarct zones, and Pcsk5 deficiency in ECs impaired angiogenesis and worsened tissue repair following MI and hindlimb ischemic injury of mice

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According to the Lilly statement, this discovery is concerning because nothing is known about the short- or long-term effects of this molecule in humans, or whether there are any potential impacts on the drugs efficacy, toxicity, or immune reactions