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In the periphery, GLP-1 agonists enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release, and slow gastric emptying

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However, in patients over 65, those with a history of prediabetes/diabetes, anyone with a cardiovascular disease, and anyone who has been severely overweight should expect to stay on medication forever due to the significant reduction in disability and death

Every labeled indication specifies use in combination with a reduced-calorie diet and increased physical activity, and trial participants were instructed to maintain approximately a 500 kcal/day deficit