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This pathway is shared with semaglutide and liraglutide

GLP-1 receptor agonists increase serotonin turnover in the brain, meaning more serotonin is being released, utilized, and recycled

This approach supports muscle retention and minimizes side effects

These prespecified analyses considered factors such as age, hypertension, heart failure, eGFR, proteinuria, new users after the index day, enrollee after 2006 and concurrent usage of other medications for glycemic control, and renin-angiotensin-aldosterone system (RAAS) blockers

Close coordination between your prescribing physician and a gastroenterologist can help ensure a safer, more comfortable experience

However, selective NaV1.7 inhibitors have repeatedly failed in the clinic, and recent studies across multiple programs point to on-target autonomic and cardiovascular liabilities