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Smoking has been found to interfere with the absorption of various nutrients, including vitamin B12

Since its very hard to get an accurate measure of B12 in people, the researchers instead searched for levels of methylmalonic acid (MMA) as its levels rise when B12 levels decrease

However, no research directly compares continuous use versus cycling protocols (such as 12 weeks on, 4-8 weeks off), leaving optimal long-term strategies somewhat uncertain

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