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The therapeutic effects are mediated through exosomal miRNA-initiated signaling pathways involving axes of the miR-486-5p/SP5/cyclin D2 [94], the miR-126/sprouty-related EVH1 domain containing 1 (SPRED1)/ERK1/2 [98], the miR-125a/Drosophila delta-like 4 homolog (DLL4) [99], and the miR-31/factor-inhibiting HIF-1 (FIH1)/HIF-1 [101]

[PubMed] National Institutes of Health

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In time-course experiments, 2012 induced a dose- and time-dependent induction of apoptosis, whereas 2020 (negative control) and defactinib had no effect at any timepoint (Supplementary Fig

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