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In clinical trial settings, retatrutide is administered as a once-weekly subcutaneous injection into the abdomen or outer thigh

Endocrinology 143 : 185190 Reimer MK et al

A modest increase in heart rate of a few beats per minute was also noted, consistent with a known class effect of GLP-1 receptor agonists

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Research from the American Journal of Physiology found that IGF-1 administration during energy deficit reduced muscle protein breakdown by approximately 18% compared to deficit alone

3 European Journal of EndocrinologySelectivity of Ipamorelin: GH release without significant ACTH, cortisol or prolactin elevation