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Your healthcare provider may recommend a brief medication-free interval to allow tirzepatide clearance before initiating semaglutide

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We thank Christopher Koscher for his assistance with protein expression and purification and Florian Grebien for help with establishing the RPE-1 cell lines stably expressing p53 and p53 mutants

It is absorbed into the pulmonary circulation but does not produce unwanted systemic effects as it has a short half-life, as a result of binding to haemoglobin

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