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Furthermore, the development of novel GPER antagonists is continually advancing [281, 282]

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[Google Scholar] 12.Weiss H.A., Buve A., Robinson N.J., Van Dyck E., Kahindo M., Anagonou S., Musonda R., Zekeng L., Morison L., Carael M., et al

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Although neither of these recent structures showed simultaneous interactions between the JAK molecule and both Box1 and Box2 sequences, geometrically both sequences are capable of binding to single JAK protein (73, 74)