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Both carry the FDA boxed warning for medullary thyroid carcinoma based on rodent studies
Ozempic can cause dizziness through dehydration from gastrointestinal side effects (nausea, vomiting, diarrhoea), reduced fluid and caloric intake due to appetite suppression, blood pressure changes (especially with concurrent antihypertensive medications), and hypoglycaemia when combined with insulin or sulfonylureas
Rapid weight loss can also increase the risk of gallstone formation
Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes Huang Y, He Y, Makarcyzk MJ, Lin H Frontiers in Bioengineering and Biotechnology (2021) This study demonstrated that FOXO4-DRI selectively removes senescent cells from human chondrocyte cultures expanded in vitro, providing direct evidence of the peptide's senolytic activity in human cells relevant to joint and cartilage aging
This observation suggests that even patients with HS without obesity might benefit from this therapeutic class
Ethics committee approval This study protocol was approved by the Ethics Committee of Shiraz University of Medical Sciences and performed in accordance with the Ethical Standards laid down in the 1964 Declaration of Helsinki and its later amendments
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