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The answer comes down to bioavailability

Compounded tirzepatide works through the same dual-receptor mechanism as brand-name versions

When exposed to endotoxin (LPS), IL-1, or IL-6, these cells rapidly increase GLP-1 secretion in both mice and humans, highlighting GLP-1 as a key communicator between the gut, immune system, and systemic inflammation

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2004, Isidori et al