Treatments comprised 1 M oligomycin (Sigma-Aldrich, 75351), 1.5 M FCCP (Sigma-Aldrich, C2920) and 100 nM rotenone (Sigma-Aldrich, R8875) plus 1 M antimycin A (Sigma-Aldrich, A8674)
In vitro and mechanistic studies (weakest for clinical conclusions) Cell culture studies showing peptides protecting retinal cells from various insults (oxidative stress, glucose toxicity, inflammatory cytokines, hypoxia)
GSH has many different roles, including protection against reactive oxygen species and the maintenance of protein thiol groups
10.1016/j.freeradbiomed.2018.10.426 Free Radic
Baig MH, Ahmad K, Rabbani G, Choi I (2018) Use of peptides for the management of Alzheimers disease: diagnosis and inhibition
MalloyVLPerroneCEMattocksDALAblesGPCaliendoNSOrentreichDSet alMethionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice