tirzepatide weight loss side effects caused roughly half as many patients to stop treatment because of gastrointestinal as semaglutide. In the first major head-to-head obesity trial, GI side effects caused treatment discontinuation in: Tirzepatide Zepbound (Tirzepatide) for Chronic Weight

Since these medications have established safety profiles in approved metabolic indications, researchers feel they could potentially be repurposed for addiction treatment more quickly than entirely new drugs, although safety and tolerability in people with alcohol or substance use disorders still require dedicated testing

This may partly because SGLT2i users at baseline were few (15.6%) and renal events occurred later than MACE in the FLOW

Hollenstein K, Kean J, Bortolato A, Cheng RK, Dore AS, et al

doi:10.1007/s00125-023-05956-x Qureshi N, Wesolowicz L, Stievater T, Lin AT

Overall, this work proposed a convenient, safe, and effective rectal drug delivery strategy, providing a new candidate for the prevention and treatment of radiation-induced proctitis, and also providing a reference for the design of multifunctional local delivery systems in radiation-associated tissue injury

It can be raised close to the dosage of Wegovy which so far leads to the most weight loss (about 15%) out of all the weight loss medications available in Canada today