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Adults 18 and older on Medicare Part D who meet one of three BMI tiers at the time GLP-1 therapy is initiated: BMI 35, BMI 30 with a comorbidity (heart failure with preserved EF, uncontrolled hypertension despite two antihypertensives, or chronic kidney disease stage 3a+), or BMI 27 with a cardiovascular comorbidity (pre-diabetes by ADA criteria, prior heart attack, prior stroke, or symptomatic peripheral artery disease)

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For example, the intravenous administration of ghrelin twice daily for half a month led to a notable enhancement in appetite and a potential increase in the daily food intake among patients with FD experiencing appetite loss (132)

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