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What It May Support Activates both GIP and GLP-1 receptors, a combined mechanism associated with stronger average results in clinical trials

Some patients report that night-time dosing allows them to sleep through initial side effects, though there is no conclusive clinical evidence that timing categorically reduces nausea

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as diphenhydramine, promethazine)

Learn more about getting a GLP1 prescription and what to expect

Rotating injection sites with each dose helps prevent lipodystrophy, which is the breakdown or buildup of fat tissue at the injection site

There is no evidence that blood clots are associated with higher doses of semaglutide, she explains