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Abbreviations Author Contributions Conceptualization, A.A

This mechanism suggests that mitochondrial damage not only causes energy insufficiency but also may transform localized cellular stress into systemic inflammation via immune signaling, providing a potential precursor for subsequent neuroinflammation in PEM

Depression and anxiety involve multiple overlapping systems in the brain, from neurotransmitter imbalances to chronic neuroinflammation to disrupted gut-brain signaling

Borbe JBC, Elvambuena BF, Eugenio FAD, Tan RJM

Multiple studies have evaluated LC symptoms in hospitalized patients, inevitably including only the more severe end of the spectrum (68)