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For the SPRDtgHD rat tissues, 8-month-old animals were killed via transcardial perfusion with perfusion buffer (0.01 M PBS, pH 7.4)

Both glutamine and glutathione are naturally occurring in the body and are generally very well-tolerated

The physiological basis of our model is the reaction diagram [Figure 1] and the K m values for the enzymes

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Further evidence was provided by a time-course western blot analysis of striatal GSTO2 and TH protein levels, showing GSTO2 upregulation before TH increase by 1 month (Figs

These changes may lead to sensations of dizziness or episodes of fainting if not adequately observed