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Although radiation therapy is effective in prolonging patient survival, local recurrences may actually be promoted by radiation therapy through activation of EGFR, IGF-1R, and PDGFR [107, 108], while inhibition of these pathways increases radiosensitivity [108]

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Many other molecules that participate in autophagy routing are selective receptors (SAR) for cargos to be degraded by lysosomal enzymes (Venediktov et al., 2023), although HSP70s may also engage additional machinery

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