tirzepatide gastrointestinal side effects compared to semaglutide caused roughly half as many patients stop treatment because of as semaglutide. In the first major head-to-head obesity trial, GI side effects caused treatment discontinuation in: Tirzepatide Semaglutide vs. Tirzepatide… aka: which

In fact, in head-to-head studies, Tirzepatide not only lowered HbA1c more effectively than existing medications like semaglutide, but also helped patients lose more body weight, with some losing over 20% of their total body weight in extended trials

It is contraindicated for individuals with uncontrolled high blood pressure, seizure disorders, current use of bupropion products, bulimia, anorexia nervosa, chronic opioid use, current opioid agonist use, and known allergies to its components

So what they study found

In women, weight loss may affect oestrogen metabolism and could potentially unmask or coincide with perimenopausal symptoms, including hot flushes

[DOI] [PubMed] [Google Scholar] 211.Casero C, Machin F, Mendez-Alvarez S, et al

Lv, X., Chen, Z., Li, J., Zhang, L., Liu, H., Huang, C