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The biological basis for these actions is GHK (Tripeptide-1), a peptide generated during tissue damage with a very high affinity for copper (Cu 2+ )

Only fatty acids bound to carnitine are used for energy production, whereby the heart can cover 80% and the skeletal muscles 50% of their energy requirements by burning fatty acids

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Twenty-three patients in 16 families with similar clinical manifestations and two mutations in the COQ6 gene have been identified to date [65-71]

Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937

Understanding the safety profile, monitoring requirements, and potential physiological interactions of these therapies is essential for anyone contemplating combined treatment