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The novelty of this review lies in its integrative approach, moving beyond a mere description of disparate pathways to synthesize a coherent framework that connects key metabolic nodessuch as the mammalian target of rapamycin (mTOR)-hypoxia-inducible factor 1-alpha (HIF-1)-glycolysis axis, AMP-activated protein kinase (AMPK)-FAO signalinginto a dynamic immunometabolic network ( Figure 1 )

Cadmium toxicity Cadmium (Cd) is one of the most toxic hazards exposed in industrial workplaces, and agricultural plants and soils due to frequent use of Cd-containing fertilizers, pesticides, and herbicides (Figure 2) [16]