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Key gaps include: No large-scale randomised controlled trials in humans the evidence basis for clinical use is extrapolated from animal data and small pilot studies No long-term safety data effects beyond 1216 weeks are not well characterised Variable results in human sleep trials some early human studies showed modest or inconsistent effects on sleep architecture compared to animal data, suggesting the translation may not be linear No FDA approval DSIP is not approved for any therapeutic use in the United States Stability concerns DSIP degrades relatively quickly in circulation

Kawamoto, Y., Wu, Y., Takahashi, Y

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Zafar says she is encountering more patients who use it

Importantly, a recent study showed that treating mice with doxycycline, an antimicrobial drug that systemically affects the function of mitoribosomes, and therefore disrupts mitochondrial translation, leads to an increased tolerance against Escherichia coli infection without affecting the pathogen load [51]

Despite barriers, GLP-1 coverage seen as an attractive and desired benefit Most HR decision-makers are open to adding GLP-1 medications to their benefits package 81% feel their employees are interested