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Inhibition of GIP- and GLP-1-stimulated cAMP production by (Pro 3 )GIP and exendin(939)amide Only very weak stimulation of cAMP stimulation was observed when 10 12 to 10 6 mol/l of either (Pro 3 )GIP or exendin(939)amide were applied to fibroblasts stably transfected with the human GIP receptor (912% increase)

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It acts together with locally secreted ghrelin in the hypothalamus to stimulate the NPY and other neurons in the ARC-PVN nucleus to stimulate the appetite

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