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Clinical trials have not consistently shown improvement in cognitive function among older adults with or without dementia when supplemented with vitamin B12 alone or in combination with other B vitamins, even when blood concentrations of homocysteine come down

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Because the reaction consumes both nicotinamide and a methyl donor, changes in NNMT expression may influence the availability of metabolites associated with NAD turnover and methylation balance

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Studies show that drinking alcohol, even moderately, can reduce vitamin B12 absorption by about 5-6%

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