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doi: 10.3389/fmicb.2019.02000 Received 05 May 2019 Accepted 15 August 2019 Published 30 August 2019 Volume 10 - 2019 Edited by Henrietta Venter, University of South Australia, Australia Reviewed by Csar de la Fuente, Massachusetts Institute of Technology, United States

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4 Conclusion and future directions Over the past decades, medicine has already undergone a notably transformation, shifting from a sick care approach, which centered mainly on the treatment of diseases after manifestation, to a healthcare paradigm that proactively identifies and mitigates specific risk factors to prevent the manifestation of diseases