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B12 deficiencies can lead to skin hyperpigmentation, vitiligo, changes to your hair, nail discolouration, and angular stomatitis (where the corners of your mouth become red and cracked)

By 2022, it had become a blockbuster

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The results of immunofluorescence staining of the synovial tissues indicated that, compared with the NC group, the proportion of CD68 + CD86+ M1 macrophages significantly increased in the RA group, while the proportion of CD68 + CD206+ M2 macrophages did not change significantly

The company also noted that the rate of elevated liver enzymes in people who have taken danuglipron is in line with approved GLP-1 drugs, which is based on a safety database of more than 1,400 patients who have taken Pfizer's pill