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Compared with the wild type, the mutant cells showed no activated expression of three key lipolysis genes, ATGL, HSL, and LIPC after GLP-1 treatment (Figure 3C), while GLP-1 still upregulated the transcription of the truncated FNDC5 mRNA

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doi: 10.1007/s12035-017-0550-2 140 SolmazVCinarBPYigitturkGCavusogluTTaskiranDErbasO

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Additionally, due to the high reactive activity of NO, the synergistic antibacterial effect of NO and ROS at diabetic wound sites was significant

Current challenges in NADs development Unlike traditional small molecules and antibody drugs that exert their pharmacological effects on proteins, most NADs directly regulate gene expression, offering a broader range of targets