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This biological approach is at the heart of modern metabolic health

GLP-1 receptor agonists are drugs that mimic this hormone, signaling the brain to reduce hunger and make other metabolic changes

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However, high agonist efficacy might result not only from a propensity to stabilize conformer 1, but also from an ability to promote G protein turnover, which could be hindered if conformer 1 were too long-lived

Chen, M., Patel, S., & OConnor, D