The ROS generated from aerobic respiration caused a cumulative oxidative damage in macromolecules, including lipids, DNA, and proteins, which subsequently lead to cells death (Scheibye-Knudsen et al., 2015), and affect the healthspan of numerous principal organ systems (Dai et al., 2014)
Mitochondrial quality control mechanisms have been recently found to control cellular identity and maturity in metabolically relevant tissues 60 , including in pancreatic -cells, highlighting the importance that mitochondria have in the control of -cell function
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Heterozygous carriers have an enzyme activity of about 55% of the normal mean and normal levels of glutathione [18]
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