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At the formulation level, this GLP-1 analog features a substitution at position 34, replacing lysine with arginine

Animal reproductive toxicity studies conducted with GLP-1 receptor agonists as a class have raised concerns, and human data are insufficient to establish safety

The GLP-1-activated neurons in the brain also limit appetite for a while after a large meal (e.g., the thought of eating is unappealing for many hours after pigging out on pizza).[ref] Stress-related appetite suppression: Additionally, the GLP-1 neurons activate during times of acute stress to suppress appetite

NOTE: The GLP-1 drug class is FDA-approved in ages 12+

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