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Abbreviations AD Alzheimers disease ALS Amyotrophic lateral sclerosis APOE Apolipoprotein E ATP adenosine triphosphate HB beta-hydroxybutyric acid FA fatty acids GABA gamma-amino butyric acid KB ketone bodies KD Ketogenic diet MAD Modified Atkins diet MCT medium-chain triglyceride MS multiple sclerosis PD Parkinsons disease PEO progressive external ophtalmoplegia PPAR peroxisome proliferator activated receptor PUFA polyunsaturated fatty acids RCT randomized controlled trial ROS reactive oxygen species SGLT2 sodium-glucose cotransporter-2 UCP uncoupling proteins VLCKD very-low-carbohydrate ketogenic diet

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Casta-Abad MT, Godoy P, Bertran S, Montserrat-Capdevila J, Ortega M

Heegaard PM

10.1016/j.neuron.2013.07.014 Neuron 212 ZhouQ.HommaK

These protective functions are likely rewired in many neurological and neurodegenerative disorders in the adult