However, recent attention has been drawn to its potential use in weight loss
Safety profiles vary significantly : IV administration carries serious risks including anaphylaxis, hepatotoxicity, and potential endotoxin contamination, while oral supplements typically cause only mild gastrointestinal effects like flatulence or loose stools
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Antidiarrheal medications such as loperamide (Imodium), but only if deemed safe
This response is defective in gustducin -null mice, which have an impaired GLP-1 response to luminal glucose (152)
In summary, androgens/AR signaling regulates mitochondrial biogenesis by enhancing the PGC-1/NRF-1/TFAM pathway and affecting mtDNA copy number and OXPHOS through localization to mitochondria