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54.9% The lean mass preserved additionally in participants receiving apitegromab alongside tirzepatide in the phase 2 EMBRAZE trial, compared with tirzepatide and placebo, while achieving similar overall weight loss

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In contrast, mitochondrial PRDX3 undergoes hyperoxidation during lipid peroxidation stress and translocates to the plasma membrane, where it suppresses cystine uptake, depletes intracellular GSH, and amplifies ferroptotic execution 114

Q: Can I combine these medications with other weight loss treatments