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Week 3-6: peak severity This is typically when constipation is at its worst
The published tirzepatide efficacy data including the 72-week trials reporting mean weight changes up to 20.9% were generated with subcutaneous injection, so those results cannot be assumed to transfer to an oral compounded preparation that has not been studied the same way
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Dietary optimization remains foundational regardless of medication use
Adjusting meal size and composition resolves this for most people
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