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Vitiligo : A randomized multicenter trial showed that afamelanotide combined with NB-UVB phototherapy achieved 48.64% mean VASI improvement versus 33.26% with phototherapy alone

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GPNMB expression was also increased in senescent human umbilical vein endothelial cells, in endothelial cells from old mice, and in several other tissues such as bone marrow and lungs 62 , suggesting that GPNMB could be a potential target in senescence-related pathological conditions