Studies have explored how this compound interacts with copper-dependent enzymes including lysyl oxidase, which plays a critical role in collagen and elastin crosslinking
HIV protease inhibitorsritonavir, indinavir, saquinavir, nelfinavir, and zidovudinewere described as ABCC1 substrate [35], suggesting that the overexpression of ABCC1 in infected cells makes these cells more resistant to chemotherapy
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However, the phenomenon may not be uniform since MRI scans in patients with glioblastoma have shown that the BBB is intact in some brain regions (Sarkaria et al., 2018)
Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions
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