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One of the underlying causes of PCOS is thought to be insulin resistance

Once you've confirmed semaglutide is the culprit and managed it successfully, nausea typically becomes a non-issue

[DOI] [PMC free article] [PubMed] [Google Scholar] 182.Moix Gil E

In the context of T2DM, the adipokine secretory profile becomes dysregulated, with reduced levels of insulin-sensitizing adipokines and increased secretion of pro-inflammatory adipokines and cytokines, thereby disrupting metabolic homeostasis [22]

These symptoms could indicate gastroparesis (severely delayed stomach emptying) or other complications requiring medical assessment

& Mcewen, S