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In the case of animals inoculated peripherally with scrapie, the agent propagates along peripheral sensory and autonomic nerves in the peritoneum to enter the spinal cord and medulla, and then ascends to invade the brain (Kimberlin and Walker, 1982)

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This metabolic stability contrasts sharply with full-length growth hormone, which can cause glucose intolerance, elevated blood sugar, and insulin resistance (diabetogenic effects)

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