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GLP-1 medications significantly suppress appetite, which can lead to inadequate protein consumption during rapid weight loss

The evidence suggests that without deliberate intervention, patients on GLP-1 therapies may lose a significant proportion of their weight from lean mass, a finding that has considerable implications for long-term metabolic health, physical function, and the sustainability of results. Why Muscle Mass is Not a Cosmetic Concern When patients hear the phrase muscle loss, they frequently interpret it through an aesthetic lens

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Hereby, GLP-1RAs can diminish STAT1 activity [91]

Those taking the GLP-1 injection lost 5.26 kilograms (kg) of weight loss versus 3.64 kg in the GLP-1 pill group