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To investigate the impact of shifting from cystine-driven to GSH-driven cysteine supply in cancer cells in an unbiased manner, we performed a multifunctional approach to pharmacological screening (MAPS) with a library of 240 metabolic inhibitors (Fig

Symptoms will occur at the injection site and may include redness, swelling, itching, pain, and warmth

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In order to maintain the steady state of ROS, other antioxidant pathways will become more active after IDH1 mutation