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10.1186/s13073-023-01162-x 5 ArgelaguetR.VeltenB.ArnolD.DietrichS.ZenzT.MarioniJ

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SURMOUNT-1 (Jastreboff 2022, NEJM) showed up to 20.9 percent with tirzepatide at 72 weeks

There are currently no established safety data specifically addressing GLP-1 agonist use in active Crohn's disease, requiring thorough informed consent, close monitoring, and coordination between specialists

This mechanism ensures that large amounts of ATP are formed only at high glucose levels (Glc transporter SLC2A2 is active at higher levels, normal Glc level is 3.6 - 5.5 mmol/l)

By understanding the mechanisms of iron-induced oxidative stress and implementing comprehensive, science-based interventions, we can significantly reduce this risk