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Antioxidant enzymes such as catalase, glutathione peroxidase, and MnSOD remain vital to cellular defense, and FOXO4-DRI has been considered a tool to examine senescence while maintaining these protective systems

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39 The outcome of these studies reinforces the notion that the intestinal epithelium is essential for separating luminal antigens from mucosal immune components, and that its disruption by altered proliferation/apoptosis ratio can result in immune activation and inflammation (Figure 1)