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In mice that have combined KO of ghr and igf1 , the growth deficiency is significantly more severe than in each individual KO (322), indicating that GH has growth mediating effects that are independent of IGF-1
Practitioners may consider Sermorelin when physiological GH-axis support with maintained pulsatility is the goal, and IGF-1 DES when localized muscle anabolism at the receptor level is the primary research objective
Much of the research on it is in Russian, not English, so scientific literature about its effects and mechanisms can be challenging to find, much less analyze
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You should be especially careful with electrolyte supplements if you have kidney disease, heart problems, high blood pressure, diabetes complications, fluid restrictions, a history of electrolyte imbalance, or if you take diuretics or blood pressure medications
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