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Moreover, the consumption of omega-3 is associated with activating the AMPK (AMP-activated protein kinase) pathway, which acts as a sensor of the cellular energy state that regulates energy homeostasis between lipid oxidation and lipogenesis

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It may also be inconsistent, and only be effective on some parts of the body

GPX4-independent antioxidant mechanisms Following the inactivation of GPX4, some cancer cells still remain resistant to ferroptosis [67, 68], implying that there are other ferroptosis defence mechanisms