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For severe deficiency, patients get 1,000 mcg daily for the first week

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The first day you descend about 15 km to the river, the second day you climb 12 km to Santa Rosa, the third day you climb 8 km to Choquequirao, and the fourth and fifth days you return

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H2 Blockers such as cimetidine, famotidine and ranitidine

Ok, so these are interesting points but please add this into the mix for future answers: The NICE Guideline clearly states that there is insufficient research why some people need more frequent injections than others and that an 8- or 12- weekly schedule does not work for everyone and some may need more frequently