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Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota

DOI: 10.1111/1440-1681.12230 86

The SURMOUNT trials showed tirzepatide at 15 mg achieving 15% to 21% weight loss by week 72, compared to semaglutide at 2.4 mg achieving approximately 15% by week 68

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9 These clinical findings are consistent with preclinical data that berberine activates AMPK and favorably alters lipid metabolism, but the trial did not directly measure GLP-1 or gut microbiota composition