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Notably, GLP-1 receptor activation in afferent arterioles induces vasodilation, thereby enhancing glomerular filtration while simultaneously reducing intraglomerular pressure

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Pochini et al., 2013

102,313 Uric acid directly affects endothelial cells by reducing nitric oxide levels, influencing processes such as vascular smooth muscle cell proliferation, extracellular matrix deposition, and the adhesion and migration of macrophages

Dobberfuhl, A.D., van Uem, S